B Cell Activating Factor (BAFF) and T Cells Cooperate to Breach B Cell Tolerance in Lupus-Prone New Zealand Black (NZB) Mice

The presence of autoantibodies in New Zealand Black (NZB) mice suggests a B cell tolerance defect however the nature of this defect is unknown. To determine whether defects in B cell anergy contribute to the autoimmune phenotype in NZB mice, soluble hen egg lysozyme (sHEL) and anti-HEL Ig transgenes...

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Detalhes bibliográficos
Main Authors: Chang, Nan-Hua, Cheung, Yui-Ho, Loh, Christina, Pau, Evelyn, Roy, Valerie, Cai, Yong-Chun, Wither, Joan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908288/
https://ncbi.nlm.nih.gov/pubmed/20661465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011691
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