TLR Tolerance Reduces IFN-Alpha Production Despite Plasmacytoid Dendritic Cell Expansion and Anti-Nuclear Antibodies in NZB Bicongenic Mice

Genetic loci on New Zealand Black (NZB) chromosomes 1 and 13 play a significant role in the development of lupus-like autoimmune disease. We have previously shown that C57BL/6 (B6) congenic mice with homozygous NZB chromosome 1 (B6.NZBc1) or 13 (B6.NZBc13) intervals develop anti-nuclear antibodies a...

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Detalhes bibliográficos
Main Authors: Pau, Evelyn, Cheung, Yui-Ho, Loh, Christina, Lajoie, Ginette, Wither, Joan E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344944/
https://ncbi.nlm.nih.gov/pubmed/22574220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036761
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