Increasing procaspase 8 expression using repurposed drugs to induce HIV infected cell death in ex vivo patient cells

HIV persists because a reservoir of latently infected CD4 T cells do not express viral proteins and are indistinguishable from uninfected cells. One approach to HIV cure suggests that reactivating HIV will activate cytotoxic pathways; yet when tested in vivo, reactivating cells do not die sufficient...

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Veröffentlicht in:PLoS One
Hauptverfasser: Sampath, Rahul, Cummins, Nathan W., Natesampillai, Sekar, Bren, Gary D., Chung, Thomas D., Baker, Jason, Henry, Keith, Pagliuzza, Amélie, Badley, Andrew D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476266/
https://ncbi.nlm.nih.gov/pubmed/28628632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179327
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