The HECT family ubiquitin ligase EEL-1 regulates neuronal function and development

Genetic changes in the HECT ubiquitin ligase HUWE1 are associated with intellectual disability, but it remains unknown whether HUWE1 functions in post-mitotic neurons to affect circuit function. Using genetics, pharmacology and electrophysiology, we show that EEL-1, the HUWE1 ortholog in C. elegans,...

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發表在:Cell Rep
Main Authors: Opperman, Karla J., Mulcahy, Ben, Giles, Andrew C., Risley, Monica G., Birnbaum, Rayna L., Tulgren, Erik D., Dawson-Scully, Ken, Zhen, Mei, Grill, Brock
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475272/
https://ncbi.nlm.nih.gov/pubmed/28445732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.04.003
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