TRTH-15. RESISTANCE MECHANISMS TO BET-BROMODOMAIN INHIBITION IN MYC-AMPLIFIED MEDULLOBLASTOMA

INTRODUCTION: Children with MYC-amplified medulloblastoma face a dismal prognosis. We have previously found BET-bromodomain inhibition to have preclinical promise as a therapeutic strategy for MYC-amplified medulloblastoma. However, the mechanisms of action of these inhibitors have not been fully el...

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Pubblicato in:Neuro Oncol
Autori principali: Bandopadhayay, Pratiti, Paolella, Brenton, O’Rourke, Ryan, Ho, Patricia, Greenwald, Noah, Sharpira, Ofer, Pantel, Sasha, Bagul, Mukta, Tracy, Adam, Roti, Giovanni, Balboni, Amanda, Vazquez, Francisca, Ligon, Keith, Piccioni, Federica, Stegmaier, Kimberly, Johannessen, Cory, Beroukhim, Rameen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475201/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.227
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