MEDU-44. TARGETING SHH SIGNALING VIA PI3K/MTOR INHIBITION IN MEDULLOBLASTOMA AND EWING SARCOMA

BACKGROUND: The phosphoinositide 3-kinase (PI3K) and sonic hedgehog (SHH) pathways play important roles in medulloblastoma (MB) and other pediatric cancers. Aberrant activation of the PI3K pathway has been shown to be an important regulator of cancer cell proliferation, metabolism, protein synthesis...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Clymer, Jessica, Eckerd, Frank, Bell, Jonathan, Lulla, Rishi, Goldman, Stewart, Platanias, Leonidas
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2017
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Abstracts
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475169/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.194
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