MEDU-44. TARGETING SHH SIGNALING VIA PI3K/MTOR INHIBITION IN MEDULLOBLASTOMA AND EWING SARCOMA

BACKGROUND: The phosphoinositide 3-kinase (PI3K) and sonic hedgehog (SHH) pathways play important roles in medulloblastoma (MB) and other pediatric cancers. Aberrant activation of the PI3K pathway has been shown to be an important regulator of cancer cell proliferation, metabolism, protein synthesis...

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izdano v:Neuro Oncol
Main Authors: Clymer, Jessica, Eckerd, Frank, Bell, Jonathan, Lulla, Rishi, Goldman, Stewart, Platanias, Leonidas
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Abstracts
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475169/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.194
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