MEDU-44. TARGETING SHH SIGNALING VIA PI3K/MTOR INHIBITION IN MEDULLOBLASTOMA AND EWING SARCOMA

BACKGROUND: The phosphoinositide 3-kinase (PI3K) and sonic hedgehog (SHH) pathways play important roles in medulloblastoma (MB) and other pediatric cancers. Aberrant activation of the PI3K pathway has been shown to be an important regulator of cancer cell proliferation, metabolism, protein synthesis...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Clymer, Jessica, Eckerd, Frank, Bell, Jonathan, Lulla, Rishi, Goldman, Stewart, Platanias, Leonidas
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475169/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.194
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