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GENE-11. LSD1/KDM1A MODULATES AN ONCO-IMMUNOGENIC GENE SIGNATURE IN ADULT GBM AND EPIGENOME-MUTATED PEDIATRIC DIPG
Diffuse intrinsic pontine glioma (DIPG) patients often possess a lysine-to-methionine mutation in histone H3 (H3.1/.3-K27M) that renders them sensitive to perturbations in histone methylation. However, the demethylase KDM1A/LSD1 has not yet been investigated as a therapeutic target in DIPG. Our lab...
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| Izdano u: | Neuro Oncol |
|---|---|
| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5475047/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.082 |
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