DIPG-42. THE COMBINATION OF THE CDK4/6 INHIBITOR PALBOCICLIB WITH THE RAPALOGUE TEMSIROLIMUS INHIBITS DIPG CELL PROLIFERATION VIA SYNERGISTIC ATTENUATION OF CELL CYCLE REGULATORS

Current chemotherapy for diffuse intrinsic pontine glioma (DIPG) is ineffective and requires revitalization. DIPG accounts for up to 15% of all childhood central nervous system tumours and has a two-year survival rate of less than 10%. DIPG is highly chemotherapy-resistant and children show little r...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Asby, DJ, Bienemann, AS, Wright, LJ, Killick-Cole, C, Singleton, WGB, Wyatt, MJ, Barua, NU, Gill, SS
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475022/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.057
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