DIPG-27. CLEE011XUS17T (NCT 02607124): A PHASE I/II STUDY OF RIBOCICLIB (LEE011) FOLLOWING RADIATION THERAPY IN CHILDREN WITH NEWLY DIAGNOSED NON-BIOPSIED DIFFUSE PONTINE GLIOMAS (DIPG) AND RB+ BIOPSIED DIPG AND HIGH GRADE GLIOMAS (HGG)

Genomic sequencing studies have uncovered alterations of checkpoint cell cycle regulators (CDK4/6, CDK2NA) in diffuse intrinsic pontine gliomas (DIPG) and high-grade gliomas (HGG). Ribociclib (LEE011) is an orally bioavailable, small molecule inhibitor of CDK4/CyclinD1 and CDK6/CyclinD3 complexes re...

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Publicat a:Neuro Oncol
Autors principals: DeWire, Mariko, Fuller, Christine, Hummel, Trent, Chow, Lionel M.L., Salloum, Ralph, Pater, Luke, Drissi, Rachid, Lu, Qing, Stevenson, Charles, Lane, Adam, Breneman, John, Witte, David, Leach, James, Fouladi, Maryam
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Abstracts
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475016/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.042
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