BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS

Many pediatric cancers exhibit widespread somatic copy number alterations. We integrated a genome-scale shRNA viability screen and copy number profiles from 179 cancer cell lines to perform an unbiased analysis of copy-number associated gene-dependency interactions. We found most copy-number associa...

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Publicado no:Neuro Oncol
Main Authors: Paolella, Brenton, Gibson, William, Urbanski, Laura, Alberta, John, Zack, Travis, Bandopadhayay, Pratiti, Nichols, Caitlin, Brown, Meredith, Lamothe, Rebecca, Yu, Yong, Choi, Peter, Obeng, Esther, Wei, Guo, Wong, Belinda, Tsherniak, Aviad, Vazquez, Francisca, Weir, Barbara, Root, David, Cowley, Glenn, Stiles, Charles, Ebert, Benjamin, Hahn, William, Reed, Robin, Beroukhim, Rameen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474993/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.012
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