ATRT-09. CHROMATIN SEGMENTATION ANALYSES IN ATYPICAL TERATOID/RHABDOID TUMORS REVEAL H3K27ME3-MEDIATED EPIGENETIC SILENCING OF TUMOR SUPPRESSOR GENES AND IDENTIFY A NOVEL ROLE OF EZH2, ASSOCIATED WITH ACTIVE CHROMATIN

Although SMARCB1 mutations represent the only genetic aberrations in atypical teratoid / rhabdoid tumors (ATRT), a comprehensive assessment of the epigenetic effect of SMARCB1 loss has not been achieved so far. We performed ChIP-sequencing for six active and repressive histone marks (H3K4me1, H3K4me...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Johann, Pascal D., Erkek, Serap, Chavez, Lukas, Finetti, Martina, Kerl, Kornelius, Zapatka, Marc, Gajjar, Amar, Hasselblatt, Martin, Pfister, Stefan M., Kool, Marcel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474972/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.008
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