G Protein-Coupled Receptors Contain Two Conserved Packing Clusters

G protein-coupled receptors (GPCRs) have evolved a seven-transmembrane helix framework that is responsive to a wide range of extracellular signals. An analysis of the interior packing of family A GPCR crystal structures reveals two clusters of highly packed residues that facilitate tight transmembra...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Sanchez-Reyes, Omar B., Cooke, Aidan L.G., Tranter, Dale B., Rashid, Dawood, Eilers, Markus, Reeves, Philip J., Smith, Steven O.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2017
Assuntos:
Channels and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474883/
https://ncbi.nlm.nih.gov/pubmed/28591604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.051
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