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Pathogenic cysteine removal mutations in FGFR extracellular domains stabilize receptor dimers and perturb the TM dimer structure
Missense mutations which introduce or remove cysteine residues in receptor tyrosine kinases (RTKs) are believed to cause pathologies by stabilizing the active RTK dimers. However, the magnitude of this stabilizing effect has not been measured for full-length receptors. Here, we characterize the dime...
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| Pubblicato in: | J Mol Biol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5474753/ https://ncbi.nlm.nih.gov/pubmed/27596331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.08.026 |
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