Elastic-Fluid Model for DNA Damage and Mutation from Nuclear Fluid Segregation Due to Cell Migration

When cells migrate through constricting pores, they incur DNA damage and develop genomic variation. Experiments show that this damage is not due to DNA breakage from mechanical stress on chromatin in the deformed nucleus. Here we propose a model for a mechanism by which nuclear deformation can lead...

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Bibliographische Detailangaben
Veröffentlicht in:Biophys J
Hauptverfasser: Bennett, Rachel R., Pfeifer, Charlotte R., Irianto, Jerome, Xia, Yuntao, Discher, Dennis E., Liu, Andrea J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2017
Schlagworte:
Nucleic Acids and Genome Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474726/
https://ncbi.nlm.nih.gov/pubmed/28591600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.037
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