Elastic-Fluid Model for DNA Damage and Mutation from Nuclear Fluid Segregation Due to Cell Migration

When cells migrate through constricting pores, they incur DNA damage and develop genomic variation. Experiments show that this damage is not due to DNA breakage from mechanical stress on chromatin in the deformed nucleus. Here we propose a model for a mechanism by which nuclear deformation can lead...

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Detalles Bibliográficos
Publicado en:Biophys J
Main Authors: Bennett, Rachel R., Pfeifer, Charlotte R., Irianto, Jerome, Xia, Yuntao, Discher, Dennis E., Liu, Andrea J.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2017
Assuntos:
Nucleic Acids and Genome Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474726/
https://ncbi.nlm.nih.gov/pubmed/28591600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.037
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