載入...

Elastic-Fluid Model for DNA Damage and Mutation from Nuclear Fluid Segregation Due to Cell Migration

When cells migrate through constricting pores, they incur DNA damage and develop genomic variation. Experiments show that this damage is not due to DNA breakage from mechanical stress on chromatin in the deformed nucleus. Here we propose a model for a mechanism by which nuclear deformation can lead...

全面介紹

Na minha lista:
書目詳細資料
發表在:Biophys J
Main Authors: Bennett, Rachel R., Pfeifer, Charlotte R., Irianto, Jerome, Xia, Yuntao, Discher, Dennis E., Liu, Andrea J.
格式: Artigo
語言:Inglês
出版: The Biophysical Society 2017
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474726/
https://ncbi.nlm.nih.gov/pubmed/28591600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.037
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!