Elastic-Fluid Model for DNA Damage and Mutation from Nuclear Fluid Segregation Due to Cell Migration

When cells migrate through constricting pores, they incur DNA damage and develop genomic variation. Experiments show that this damage is not due to DNA breakage from mechanical stress on chromatin in the deformed nucleus. Here we propose a model for a mechanism by which nuclear deformation can lead...

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Bibliografski detalji
Izdano u:Biophys J
Glavni autori: Bennett, Rachel R., Pfeifer, Charlotte R., Irianto, Jerome, Xia, Yuntao, Discher, Dennis E., Liu, Andrea J.
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2017
Teme:
Nucleic Acids and Genome Biophysics
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474726/
https://ncbi.nlm.nih.gov/pubmed/28591600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.037
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