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As a Nucleus Enters a Small Pore, Chromatin Stretches and Maintains Integrity, Even with DNA Breaks

As a cell pushes or pulls its nucleus through a small constriction, the chromatin must distort and somehow maintain genomic stability despite ever-present double-strand breaks in the DNA. Here we visualize within a living cell the pore-size dependent deformation of a specific locus engineered into c...

Полное описание

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Библиографические подробности
Опубликовано в: :Biophys J
Главные авторы: Irianto, Jerome, Xia, Yuntao, Pfeifer, Charlotte R., Greenberg, Roger A., Discher, Dennis E.
Формат: Artigo
Язык:Inglês
Опубликовано: The Biophysical Society 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300774/
https://ncbi.nlm.nih.gov/pubmed/28341535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.09.047
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