DNA damage follows repair factor depletion and portends genome variation in cancer cells after pore migration

Migration through micron-size constrictions has been seen to rupture the nucleus, release nuclear-localized GFP, and cause localized accumulations of ectopic 53BP1 – a DNA repair protein. Here, constricted migration of two human cancer cell types and primary mesenchymal stem cells (MSC) increases DN...

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Publicado no:Curr Biol
Main Authors: Irianto, Jerome, Xia, Yuntao, Pfeifer, Charlotte R., Athirasala, Avathamsa, Ji, Jiazheng, Alvey, Cory, Tewari, Manu, Bennett, Rachel, Harding, Shane M., Liu, Andrea, Greenberg, Roger A., Discher, Dennis E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5262636/
https://ncbi.nlm.nih.gov/pubmed/27989676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2016.11.049
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