Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis

BACKGROUND: Despite the important role that microRNAs (miRNAs) play in immunity and inflammation, their involvement in systemic sclerosis (SSc) remains poorly characterized. miRNA-155 (miR-155) plays a role in pulmonary fibrosis and its expression can be induced with interleukin (IL)-1β. SSc fibrobl...

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Bibliographic Details
Published in:Arthritis Res Ther
Main Authors: Artlett, Carol M., Sassi-Gaha, Sihem, Hope, Jennifer L., Feghali-Bostwick, Carol A., Katsikis, Peter D.
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473986/
https://ncbi.nlm.nih.gov/pubmed/28623945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1331-z
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