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NLRP3 Inflammasome Is a Target for Development of Broad-Spectrum Anti-Infective Drugs
We describe the molecular mode of action and pharmacodynamics of a new molecular entity (NME) that induces the NLRP3 inflammasome-mediated innate immune response. This innate response reduces the pathogen load in an experimentally induced methicillin-resistant Staphylococcos aureus infection, enhanc...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3318317/ https://ncbi.nlm.nih.gov/pubmed/22290938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06372-11 |
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