NLRP3 Inflammasome Is a Target for Development of Broad-Spectrum Anti-Infective Drugs

We describe the molecular mode of action and pharmacodynamics of a new molecular entity (NME) that induces the NLRP3 inflammasome-mediated innate immune response. This innate response reduces the pathogen load in an experimentally induced methicillin-resistant Staphylococcos aureus infection, enhanc...

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Bibliographic Details
Main Authors: Thacker, James D., Balin, Brian J., Appelt, Denah M., Sassi-Gaha, Sihem, Purohit, Mitali, Rest, Richard F., Artlett, Carol M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318317/
https://ncbi.nlm.nih.gov/pubmed/22290938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06372-11
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