In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni

Several CRISPR-Cas9 orthologues have been used for genome editing. Here, we present the smallest Cas9 orthologue characterized to date, derived from Campylobacter jejuni (CjCas9), for efficient genome editing in vivo. After determining protospacer-adjacent motif (PAM) sequences and optimizing single...

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Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Kim, Eunji, Koo, Taeyoung, Park, Sung Wook, Kim, Daesik, Kim, Kyoungmi, Cho, Hee-Yeon, Song, Dong Woo, Lee, Kyu Jun, Jung, Min Hee, Kim, Seokjoong, Kim, Jin Hyoung, Kim, Jeong Hun, Kim, Jin-Soo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473640/
https://ncbi.nlm.nih.gov/pubmed/28220790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14500
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