Efficient and specific generation of knockout mice using Campylobacter jejuni CRISPR/Cas9 system

The Streptococcus pyogenes CRISPR/Cas9 (SpCas9) system is now widely utilized to generate genome engineered mice; however, some studies raised issues related to off-target mutations with this system. Herein, we utilized the Campylobacter jejuni Cas9 (CjCas9) system to generate knockout mice. We desi...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Rep
Principais autores: Lee, Jae Young, Jang, Yoo Jin, Bae, Ji Hyun, Lee, Yoon Hoo, Bae, Hee Sook, Kim, Seokjoong, Park, Sin-Gi, Koo, Ok Jae, Yeom, Su Cheong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
SHORT COMMUNICATION
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7118303/
https://ncbi.nlm.nih.gov/pubmed/32258440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2020.100752
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