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Mutations in the Pneumocystis jirovecii DHPS Gene Confer Cross-Resistance to Sulfa Drugs

Pneumocystis jirovecii is a major opportunistic pathogen that causes Pneumocystis pneumonia (PCP) and results in a high degree of mortality in immunocompromised individuals. The drug of choice for PCP is typically sulfamethoxazole (SMX) or dapsone in conjunction with trimethoprim. Drug treatment fai...

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Detalhes bibliográficos
Main Authors: Iliades, Peter, Meshnick, Steven R., Macreadie, Ian G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC547354/
https://ncbi.nlm.nih.gov/pubmed/15673759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.2.741-748.2005
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