JUN IS A KEY TRANSCRIPTIONAL REGULATOR OF THE UNFOLDED PROTEIN RESPONSE IN ACUTE MYELOID LEUKEMIA

The transcription factor JUN is frequently overexpressed in multiple genetic sub-types of acute myeloid leukemia (AML), however, the functional role of JUN in AML is not well defined. Here we report that shRNA-mediated inhibition of JUN decreases AML cell survival and propagation in vivo. By perform...

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Gepubliceerd in:Leukemia
Hoofdauteurs: Zhou, Chun, Martinez, Esteban, Di Marcantonio, Daniela, Solanki-Patel, Nehal, Aghayev, Turan, Peri, Suraj, Ferraro, Francesca, Skorski, Tomasz, Scholl, Claudia, Fröhling, Stefan, Balachandran, Siddharth, Wiest, David L., Sykes, Stephen M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473421/
https://ncbi.nlm.nih.gov/pubmed/27840425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.329
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