Caspofungin Inhibits Rhizopus oryzae 1,3-β-d-Glucan Synthase, Lowers Burden in Brain Measured by Quantitative PCR, and Improves Survival at a Low but Not a High Dose during Murine Disseminated Zygomycosis

Rhizopus oryzae is the most common cause of zygomycosis, a life-threatening infection that usually occurs in patients with diabetic ketoacidosis. Despite standard therapy, the overall rate of mortality from zygomycosis remains >50%, and new strategies for treatment are urgently needed. The activi...

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Bibliographische Detailangaben
Hauptverfasser: Ibrahim, Ashraf S., Bowman, Joel C., Avanessian, Valentina, Brown, Keturah, Spellberg, Brad, Edwards, John E., Douglas, Cameron M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC547300/
https://ncbi.nlm.nih.gov/pubmed/15673756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.2.721-727.2005
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