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Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates
Parkinson’s disease (PD) is characterized neuropathologically by intracellular aggregates of fibrillar α-synuclein, termed Lewy bodies (LBs). Approximately 90% of α-synuclein deposited as LBs is phosphorylated at Ser129 in brains with PD. In contrast, only 4% of total α-synuclein is phosphorylated a...
Gespeichert in:
| Veröffentlicht in: | Acta Neuropathol Commun |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5472914/ https://ncbi.nlm.nih.gov/pubmed/28619113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0452-6 |
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