Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein–coupled receptor kinase–dependent manner

Most α-synuclein (α-syn) deposited in Lewy bodies, the pathological hallmark of Parkinson disease (PD), is phosphorylated at Ser-129. However, the physiological and pathological roles of this modification are unclear. Here we investigate the effects of Ser-129 phosphorylation on dopamine (DA) uptake...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hara, Susumu, Arawaka, Shigeki, Sato, Hiroyasu, Machiya, Youhei, Cui, Can, Sasaki, Asuka, Koyama, Shingo, Kato, Takeo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Cell Biology 2013
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667719/
https://ncbi.nlm.nih.gov/pubmed/23576548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-12-0903
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