Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia

FAM20C mutations in humans cause Raine syndrome and our previous studies showed that global inactivation of mouse Fam20C led to bone and dental defects. By crossbreeding 2.3 kb Col 1a1-Cre mice with Fam20C (flox/flox) mice, we created 2.3 kb Col 1a1-Cre;Fam20C (foxl/flox) (cKO) mice, in which Fam2...

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Bibliographic Details
Published in:	Sci Rep
Main Authors:	Liu, Peihong, Ma, Su, Zhang, Hua, Liu, Chao, Lu, Yongbo, Chen, Li, Qin, Chunlin
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group UK 2017
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5472603/ https://ncbi.nlm.nih.gov/pubmed/28620244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03960-x
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Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia

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