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Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia

FAM20C mutations in humans cause Raine syndrome and our previous studies showed that global inactivation of mouse Fam20C led to bone and dental defects. By crossbreeding 2.3  kb Col 1a1-Cre mice with Fam20C (flox/flox) mice, we created 2.3  kb Col 1a1-Cre;Fam20C (foxl/flox) (cKO) mice, in which Fam2...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Liu, Peihong, Ma, Su, Zhang, Hua, Liu, Chao, Lu, Yongbo, Chen, Li, Qin, Chunlin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472603/
https://ncbi.nlm.nih.gov/pubmed/28620244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03960-x
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