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Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor

The μ-opioid receptor (MOPr) is a clinically important G protein-coupled receptor that couples to G(i/o) proteins and arrestins. At present, the receptor conformational changes that occur following agonist binding and activation are poorly understood. This study has employed molecular dynamics simul...

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Detaylı Bibliyografya
Yayımlandı:J Mol Biol
Asıl Yazarlar: Sutcliffe, Katy J., Henderson, Graeme, Kelly, Eamonn, Sessions, Richard B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472181/
https://ncbi.nlm.nih.gov/pubmed/28502792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.05.009
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