Genomic landscape and evolution of metastatic chromophobe renal cell carcinoma

Chromophobe renal cell carcinoma (chRCC) typically shows ~7 chromosome losses (1, 2, 6, 10, 13, 17, and 21) and ~31 exonic somatic mutations, yet carries ~5%–10% metastatic incidence. Since extensive chromosomal losses can generate proteotoxic stress and compromise cellular proliferation, it is intr...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Casuscelli, Jozefina, Weinhold, Nils, Gundem, Gunes, Wang, Lu, Zabor, Emily C., Drill, Esther, Wang, Patricia I., Nanjangud, Gouri J., Redzematovic, Almedina, Nargund, Amrita M., Manley, Brandon J., Arcila, Maria E., Donin, Nicholas M., Cheville, John C., Thompson, R. Houston, Pantuck, Allan J., Russo, Paul, Cheng, Emily H., Lee, William, Tickoo, Satish K., Ostrovnaya, Irina, Creighton, Chad J., Papaemmanuil, Elli, Seshan, Venkatraman E., Hakimi, A. Ari, Hsieh, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470887/
https://ncbi.nlm.nih.gov/pubmed/28614790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92688
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