Genomic landscape and evolution of metastatic chromophobe renal cell carcinoma

Chromophobe renal cell carcinoma (chRCC) typically shows ~7 chromosome losses (1, 2, 6, 10, 13, 17, and 21) and ~31 exonic somatic mutations, yet carries ~5%–10% metastatic incidence. Since extensive chromosomal losses can generate proteotoxic stress and compromise cellular proliferation, it is intr...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Casuscelli, Jozefina, Weinhold, Nils, Gundem, Gunes, Wang, Lu, Zabor, Emily C., Drill, Esther, Wang, Patricia I., Nanjangud, Gouri J., Redzematovic, Almedina, Nargund, Amrita M., Manley, Brandon J., Arcila, Maria E., Donin, Nicholas M., Cheville, John C., Thompson, R. Houston, Pantuck, Allan J., Russo, Paul, Cheng, Emily H., Lee, William, Tickoo, Satish K., Ostrovnaya, Irina, Creighton, Chad J., Papaemmanuil, Elli, Seshan, Venkatraman E., Hakimi, A. Ari, Hsieh, James J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470887/
https://ncbi.nlm.nih.gov/pubmed/28614790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92688
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