Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies

BACKGROUND. Plasmodium vivax is the most widespread human malaria geographically; however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite depends on an interaction between the Duffy antigen receptor for chemokines (DARC) and region II of the parasite’s Duffy-binding p...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Payne, Ruth O., Silk, Sarah E., Elias, Sean C., Milne, Kathryn H., Rawlinson, Thomas A., Llewellyn, David, Shakri, A. Rushdi, Jin, Jing, Labbé, Geneviève M., Edwards, Nick J., Poulton, Ian D., Roberts, Rachel, Farid, Ryan, Jørgensen, Thomas, Alanine, Daniel G.W., de Cassan, Simone C., Higgins, Matthew K., Otto, Thomas D., McCarthy, James S., de Jongh, Willem A., Nicosia, Alfredo, Moyle, Sarah, Hill, Adrian V.S., Berrie, Eleanor, Chitnis, Chetan E., Lawrie, Alison M., Draper, Simon J.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2017
Subjects:
Clinical Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470884/
https://ncbi.nlm.nih.gov/pubmed/28614791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93683
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