A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity

par Dicks, Matthew D. J., Spencer, Alexandra J., Edwards, Nick J., Wadell, Göran, Bojang, Kalifa, Gilbert, Sarah C., Hill, Adrian V. S., Cottingham, Matthew G.
Publié 2012

Assessment of Chimpanzee Adenovirus Serotype 63 Neutralizing Antibodies Prior to Evaluation of a Candidate Malaria Vaccine Regimen Based on Viral Vectors

par Nébié, Issa, Edwards, Nick J., Tiono, Alfred B., Ewer, Katie J., Sanou, Guillaume S., Soulama, Issiaka, Sanon, Souleymane, Diarra, Amidou, Yaro, Jean Baptiste, Kangoye, David, Imoukhuede, Egeruan B., Hill, Adrian V. S., Sirima, Sodiomon B.
Publié 2014

Correction for Nébié et al., Assessment of Chimpanzee Adenovirus Serotype 63 Neutralizing Antibodies Prior to Evaluation of a Candidate Malaria Vaccine Regimen Based on Viral Vecto...

par Nébié, Issa, Edwards, Nick J., Tiono, Alfred B., Ewer, Katie J., Sanou, Guillaume S., Soulama, Issiaka, Sanon, Souleymane, Diarra, Amidou, Yaro, Jean Baptiste, Kangoye, David, Imoukhuede, Egeruan B., Hill, Adrian V. S., Sirima, Sodiomon B.
Publié 2014

Comparison of Clinical and Parasitological Data from Controlled Human Malaria Infection Trials

par Roestenberg, Meta, O'Hara, Geraldine A., Duncan, Christopher J. A., Epstein, Judith E., Edwards, Nick J., Scholzen, Anja, van der Ven, André J. A. M., Hermsen, Cornelus C., Hill, Adrian V. S., Sauerwein, Robert W.
Publié 2012

Probability of Transmission of Malaria from Mosquito to Human Is Regulated by Mosquito Parasite Density in Naïve and Vaccinated Hosts

par Churcher, Thomas S., Sinden, Robert E., Edwards, Nick J., Poulton, Ian D., Rampling, Thomas W., Brock, Patrick M., Griffin, Jamie T., Upton, Leanna M., Zakutansky, Sara E., Sala, Katarzyna A., Angrisano, Fiona, Hill, Adrian V. S., Blagborough, Andrew M.
Publié dans PLoS Pathog (2017)

A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques

par van Doremalen, Neeltje, Haddock, Elaine, Feldmann, Friederike, Meade-White, Kimberly, Bushmaker, Trenton, Fischer, Robert J., Okumura, Atsushi, Hanley, Patrick W., Saturday, Greg, Edwards, Nick J., Clark, Madeleine H. A., Lambe, Teresa, Gilbert, Sarah C., Munster, Vincent J.
Publié dans Sci Adv (2020)

Safety and Immunogenicity of a Novel Recombinant Simian Adenovirus ChAdOx2 as a Vectored Vaccine

par Folegatti, Pedro M., Bellamy, Duncan, Roberts, Rachel, Powlson, Jonathan, Edwards, Nick J., Mair, Catherine F., Bowyer, Georgina, Poulton, Ian, Mitton, Celia H., Green, Nicky, Berrie, Eleanor, Lawrie, Alison M., Hill, Adrian V.S., Ewer, Katie J., Hermon-Taylor, John, Gilbert, Sarah C.
Publié dans Vaccines (Basel) (2019)

Comparison of Modeling Methods to Determine Liver-to-blood Inocula and Parasite Multiplication Rates During Controlled Human Malaria Infection

par Douglas, Alexander D., Edwards, Nick J., Duncan, Christopher J. A., Thompson, Fiona M., Sheehy, Susanne H., O'Hara, Geraldine A., Anagnostou, Nicholas, Walther, Michael, Webster, Daniel P., Dunachie, Susanna J., Porter, David W., Andrews, Laura, Gilbert, Sarah C., Draper, Simon J., Hill, Adrian V. S., Bejon, Philip
Publié 2013

Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults

par Ogwang, Caroline, Kimani, Domtila, Edwards, Nick J., Roberts, Rachel, Mwacharo, Jedidah, Bowyer, Georgina, Bliss, Carly, Hodgson, Susanne H., Njuguna, Patricia, Viebig, Nicola K., Nicosia, Alfredo, Gitau, Evelyn, Douglas, Sandy, Illingworth, Joe, Marsh, Kevin, Lawrie, Alison, Imoukhuede, Egeruan B., Ewer, Katie, Urban, Britta C., Hill, Adrian V. S., Bejon, Philip
Publié dans Sci Transl Med (2015)

Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe

par Sheehy, Susanne H., Spencer, Alexandra J., Douglas, Alexander D., Sim, B. Kim Lee, Longley, Rhea J., Edwards, Nick J., Poulton, Ian D., Kimani, Domtila, Williams, Andrew R., Anagnostou, Nicholas A., Roberts, Rachel, Kerridge, Simon, Voysey, Merryn, James, Eric R., Billingsley, Peter F., Gunasekera, Anusha, Lawrie, Alison M., Hoffman, Stephen L., Hill, Adrian V. S.
Publié 2013

External Quality Assurance of Malaria Nucleic Acid Testing for Clinical Trials and Eradication Surveillance

par Murphy, Sean C., Hermsen, Cornelus C., Douglas, Alexander D., Edwards, Nick J., Petersen, Ines, Fahle, Gary A., Adams, Matthew, Berry, Andrea A., Billman, Zachary P., Gilbert, Sarah C., Laurens, Matthew B., Leroy, Odile, Lyke, Kristen E., Plowe, Christopher V., Seilie, Annette M., Strauss, Kathleen A., Teelen, Karina, Hill, Adrian V. S., Sauerwein, Robert W.
Publié 2014

A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates

par Douglas, Alexander D., Baldeviano, G. Christian, Jin, Jing, Miura, Kazutoyo, Diouf, Ababacar, Zenonos, Zenon A., Ventocilla, Julio A., Silk, Sarah E., Marshall, Jennifer M., Alanine, Daniel G. W., Wang, Chuan, Edwards, Nick J., Leiva, Karina P., Gomez-Puerta, Luis A., Lucas, Carmen M., Wright, Gavin J., Long, Carole A., Royal, Joseph M., Draper, Simon J.
Publié dans Nat Commun (2019)

Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

par Milne, Kathryn, Ivens, Alasdair, Reid, Adam J, Lotkowska, Magda E, O'Toole, Aine, Sankaranarayanan, Geetha, Munoz Sandoval, Diana, Nahrendorf, Wiebke, Regnault, Clement, Edwards, Nick J, Silk, Sarah E, Payne, Ruth O, Minassian, Angela M, Venkatraman, Navin, Sanders, Mandy J, Hill, Adrian VS, Barrett, Michael, Berriman, Matthew, Draper, Simon J, Rowe, J Alexandra, Spence, Philip J
Publié dans eLife (2021)

Increased sample volume and use of quantitative reverse-transcription PCR can improve prediction of liver-to-blood inoculum size in controlled human malaria infection studies

par Hodgson, Susanne H, Douglas, Alexander D, Edwards, Nick J, Kimani, Domtila, Elias, Sean C, Chang, Ming, Daza, Glenda, Seilie, Annette M, Magiri, Charles, Muia, Alfred, Juma, Elizabeth A, Cole, Andrew O, Rampling, Thomas W, Anagnostou, Nicholas A, Gilbert, Sarah C, Hoffman, Stephen L, Draper, Simon J, Bejon, Philip, Ogutu, Bernhards, Marsh, Kevin, Hill, Adrian VS, Murphy, Sean C
Publié dans Malar J (2015)

Safety, Immunogenicity and Efficacy of Prime-Boost Vaccination with ChAd63 and MVA Encoding ME-TRAP against Plasmodium falciparum Infection in Adults in Senegal

par Mensah, Victorine A., Gueye, Aly, Ndiaye, Magatte, Edwards, Nick J., Wright, Danny, Anagnostou, Nicholas A., Syll, Massamba, Ndaw, Amy, Abiola, Annie, Bliss, Carly, Gomis, Jules-François, Petersen, Ines, Ogwang, Caroline, Dieye, Tandakha, Viebig, Nicola K., Lawrie, Alison M., Roberts, Rachel, Nicosia, Alfredo, Faye, Babacar, Gaye, Oumar, Leroy, Odile, Imoukhuede, Egeruan B., Ewer, Katie J., Bejon, Philip, Hill, Adrian V. S., Cisse, Badara
Publié dans PLoS One (2016)

Clinical Assessment of a Recombinant Simian Adenovirus ChAd63: A Potent New Vaccine Vector

par O’Hara, Geraldine A., Duncan, Christopher J. A., Ewer, Katie J., Collins, Katharine A., Elias, Sean C., Halstead, Fenella D., Goodman, Anna L., Edwards, Nick J., Reyes-Sandoval, Arturo, Bird, Prudence, Rowland, Rosalind, Sheehy, Susanne H., Poulton, Ian D., Hutchings, Claire, Todryk, Stephen, Andrews, Laura, Folgori, Antonella, Berrie, Eleanor, Moyle, Sarah, Nicosia, Alfredo, Colloca, Stefano, Cortese, Riccardo, Siani, Loredana, Lawrie, Alison M., Gilbert, Sarah C., Hill, Adrian V. S.
Publié 2012

Phase Ia Clinical Evaluation of the Safety and Immunogenicity of the Plasmodium falciparum Blood-Stage Antigen AMA1 in ChAd63 and MVA Vaccine Vectors

par Sheehy, Susanne H., Duncan, Christopher J. A., Elias, Sean C., Biswas, Sumi, Collins, Katharine A., O'Hara, Geraldine A., Halstead, Fenella D., Ewer, Katie J., Mahungu, Tabitha, Spencer, Alexandra J., Miura, Kazutoyo, Poulton, Ian D., Dicks, Matthew D. J., Edwards, Nick J., Berrie, Eleanor, Moyle, Sarah, Colloca, Stefano, Cortese, Riccardo, Gantlett, Katherine, Long, Carole A., Lawrie, Alison M., Gilbert, Sarah C., Doherty, Tom, Nicosia, Alfredo, Hill, Adrian V. S., Draper, Simon J.
Publié 2012

Safety and Immunogenicity of ChAd63/MVA Pfs25-IMX313 in a Phase I First-in-Human Trial

par de Graaf, Hans, Payne, Ruth O., Taylor, Iona, Miura, Kazutoyo, Long, Carol A., Elias, Sean C., Zaric, Marija, Minassian, Angela M., Silk, Sarah E., Li, Lee, Poulton, Ian D., Baker, Megan, Draper, Simon J., Gbesemete, Diane, Brendish, Nathan J., Martins, Filipa, Marini, Arianna, Mekhaiel, David, Edwards, Nick J., Roberts, Rachel, Vekemans, Johan, Moyle, Sarah, Faust, Saul N., Berrie, Eleanor, Lawrie, Alison M., Hill, Fergal, Hill, Adrian V. S., Biswas, Sumi
Publié dans Front Immunol (2021)

Protective CD8(+) T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation

par Ewer, Katie J., O’Hara, Geraldine A., Duncan, Christopher J. A., Collins, Katharine A., Sheehy, Susanne H., Reyes-Sandoval, Arturo, Goodman, Anna L., Edwards, Nick J., Elias, Sean C., Halstead, Fenella D., Longley, Rhea J., Rowland, Rosalind, Poulton, Ian D., Draper, Simon J., Blagborough, Andrew M., Berrie, Eleanor, Moyle, Sarah, Williams, Nicola, Siani, Loredana, Folgori, Antonella, Colloca, Stefano, Sinden, Robert E., Lawrie, Alison M., Cortese, Riccardo, Gilbert, Sarah C., Nicosia, Alfredo, Hill, Adrian V. S.
Publié 2013

Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals

par Hodgson, Susanne H., Ewer, Katie J., Bliss, Carly M., Edwards, Nick J., Rampling, Thomas, Anagnostou, Nicholas A., de Barra, Eoghan, Havelock, Tom, Bowyer, Georgina, Poulton, Ian D., de Cassan, Simone, Longley, Rhea, Illingworth, Joseph J., Douglas, Alexander D., Mange, Pooja B., Collins, Katharine A., Roberts, Rachel, Gerry, Stephen, Berrie, Eleanor, Moyle, Sarah, Colloca, Stefano, Cortese, Riccardo, Sinden, Robert E., Gilbert, Sarah C., Bejon, Philip, Lawrie, Alison M., Nicosia, Alfredo, Faust, Saul N., Hill, Adrian V. S.
Publié dans J Infect Dis (2015)