Increased sample volume and use of quantitative reverse-transcription PCR can improve prediction of liver-to-blood inoculum size in controlled human malaria infection studies

BACKGROUND: Controlled human malaria infection (CHMI) studies increasingly rely on nucleic acid test (NAT) methods to detect and quantify parasites in the blood of infected participants. The lower limits of detection and quantification vary amongst the assays used throughout the world, which may aff...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Hodgson, Susanne H, Douglas, Alexander D, Edwards, Nick J, Kimani, Domtila, Elias, Sean C, Chang, Ming, Daza, Glenda, Seilie, Annette M, Magiri, Charles, Muia, Alfred, Juma, Elizabeth A, Cole, Andrew O, Rampling, Thomas W, Anagnostou, Nicholas A, Gilbert, Sarah C, Hoffman, Stephen L, Draper, Simon J, Bejon, Philip, Ogutu, Bernhards, Marsh, Kevin, Hill, Adrian VS, Murphy, Sean C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318195/
https://ncbi.nlm.nih.gov/pubmed/25627033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-015-0541-6
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