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Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection

Background: Controlled human malaria infection (CHMI) studies are a vital tool to accelerate vaccine and drug development. As CHMI trials are performed in a controlled environment, they allow unprecedented, detailed evaluation of parasite growth dynamics (PGD) and immunological responses. However, C...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Hodgson, Susanne H., Juma, Elizabeth, Salim, Amina, Magiri, Charles, Kimani, Domtila, Njenga, Daniel, Muia, Alfred, Cole, Andrew O., Ogwang, Caroline, Awuondo, Ken, Lowe, Brett, Munene, Marianne, Billingsley, Peter F., James, Eric R., Gunasekera, Anusha, Sim, B. Kim L., Njuguna, Patricia, Rampling, Thomas W., Richman, Adam, Abebe, Yonas, Kamuyu, Gathoni, Muthui, Michelle, Elias, Sean C., Molyneux, Sassy, Gerry, Stephen, Macharia, Alex, Williams, Thomas N., Bull, Peter C., Hill, Adrian V. S., Osier, Faith H., Draper, Simon J., Bejon, Philip, Hoffman, Stephen L., Ogutu, Bernhards, Marsh, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264479/
https://ncbi.nlm.nih.gov/pubmed/25566206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2014.00686
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