Malaria vaccine candidate based on Duffy-binding protein elicits strain transcending functional antibodies in a Phase I trial

Reticulocyte invasion by Plasmodium vivax requires interaction of the Duffy-binding protein (PvDBP) with host Duffy antigen receptor for chemokines (DARCs). The binding domain of PvDBP maps to a cysteine-rich region referred to as region II (PvDBPII). Blocking this interaction offers a potential pat...

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Gepubliceerd in:NPJ Vaccines
Hoofdauteurs: Singh, Kavita, Mukherjee, Paushali, Shakri, Ahmad Rushdi, Singh, Ankita, Pandey, Gaurav, Bakshi, Meenakshi, Uppal, Geetanjali, Jena, Rajender, Rawat, Ankita, Kumar, Purnima, Bhardwaj, Rukmini, Yazdani, Syed Shams, Hans, Dhiraj, Mehta, Shantanu, Srinivasan, Ajay, Anil, K., Madhusudhan, R. L., Patel, Jaya, Singh, Amit, Rao, Rajeshwar, Gangireddy, Santosh, Patil, Rudrappa, Kaviraj, Swarnendu, Singh, Sanjay, Carter, Darrick, Reed, Steve, Kaslow, David C., Birkett, Ashley, Chauhan, Virander S., Chitnis, Chetan E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162314/
https://ncbi.nlm.nih.gov/pubmed/30302285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-018-0083-3
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