Type I interferons suppress viral replication but contribute to T cell depletion and dysfunction during chronic HIV-1 infection

The direct link between sustained type I interferon (IFN-I) signaling and HIV-1–induced immunopathogenesis during chronic infection remains unclear. Here we report studies using a monoclonal antibody to block IFN-α/β receptor 1 (IFNAR1) signaling during persistent HIV-1 infection in humanized mice (...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Cheng, Liang, Yu, Haisheng, Li, Guangming, Li, Feng, Ma, Jianping, Li, Jingyun, Chi, Liqun, Zhang, Liguo, Su, Lishan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470878/
https://ncbi.nlm.nih.gov/pubmed/28614789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94366
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