Long-Term Protection against Tuberculosis following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph of Mycobacterium tuberculosis

We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The ΔlysA ΔpanCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompeten...

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Bibliographic Details
Main Authors: Sambandamurthy, Vasan K., Derrick, Steven C., Jalapathy, Kripa V., Chen, Bing, Russell, Robert G., Morris, Sheldon L., Jacobs, William R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC547051/
https://ncbi.nlm.nih.gov/pubmed/15664964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.2.1196-1203.2005
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