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Long-Term Protection against Tuberculosis following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph of Mycobacterium tuberculosis
We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The ΔlysA ΔpanCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompeten...
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Auteurs principaux: | , , , , , , |
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Format: | Artigo |
Langue: | Inglês |
Publié: |
American Society for Microbiology
2005
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Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC547051/ https://ncbi.nlm.nih.gov/pubmed/15664964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.2.1196-1203.2005 |
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