Modulation of an Outer Membrane Protease Contributes to the Virulence Defect of Shigella flexneri Strains Carrying a Mutation in the virK Locus

The Shigella actin assembly protein IcsA is removed from the bacterial surface by the protease IcsP. We show that decreased intracellular spreading of virK::Tn10 mutants is due in part to significant increases in IcsP and IcsP-mediated cleavage of IcsA and that IcsP expression is a critical determin...

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Autori principali: Wing, Helen J., Goldman, Seth R., Ally, Shabeen, Goldberg, Marcia B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Molecular Pathogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC547015/
https://ncbi.nlm.nih.gov/pubmed/15664968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.2.1217-1220.2005
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