An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function

Stress granules (SG) are membrane‐less compartments involved in regulating mRNAs during stress. Aberrant forms of SGs have been implicated in age‐related diseases, such as amyotrophic lateral sclerosis (ALS), but the molecular events triggering their formation are still unknown. Here, we find that m...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Mateju, Daniel, Franzmann, Titus M, Patel, Avinash, Kopach, Andrii, Boczek, Edgar E, Maharana, Shovamayee, Lee, Hyun O, Carra, Serena, Hyman, Anthony A, Alberti, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470046/
https://ncbi.nlm.nih.gov/pubmed/28377462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695957
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