Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening

TNFα is a homotrimeric pro-inflammatory cytokine, whose direct targeting by protein biotherapies has been an undeniable success for the treatment of chronic inflammatory diseases. Despite many efforts, no orally active drug targeting TNFα has been identified so far. In the present work, we identifie...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Mouhsine, Hadley, Guillemain, Hélène, Moreau, Gabriel, Fourati, Najla, Zerrouki, Chouki, Baron, Bruno, Desallais, Lucille, Gizzi, Patrick, Ben Nasr, Nesrine, Perrier, Julie, Ratsimandresy, Rojo, Spadoni, Jean-Louis, Do, Hervé, England, Patrick, Montes, Matthieu, Zagury, Jean-François
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469758/
https://ncbi.nlm.nih.gov/pubmed/28611375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03427-z
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge