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Oxycodone Plus Ultra-Low-Dose Naltrexone Attenuates Neuropathic Pain and Associated μ-Opioid Receptor–G(s) Coupling
Both peripheral nerve injury and chronic opioid treatment can result in hyperalgesia associated with enhanced excitatory neurotransmission at the level of the spinal cord. Chronic opioid administration leads to a shift in μ-opioid receptor (MOR)–G protein coupling from G(i/o) to G(s) that can be pre...
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| Publicado no: | J Pain |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5469510/ https://ncbi.nlm.nih.gov/pubmed/18468954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2008.03.005 |
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