Oxycodone Plus Ultra-Low-Dose Naltrexone Attenuates Neuropathic Pain and Associated μ-Opioid Receptor–G(s) Coupling

Both peripheral nerve injury and chronic opioid treatment can result in hyperalgesia associated with enhanced excitatory neurotransmission at the level of the spinal cord. Chronic opioid administration leads to a shift in μ-opioid receptor (MOR)–G protein coupling from G(i/o) to G(s) that can be pre...

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Udgivet i:J Pain
Main Authors: Largent-Milnes, Tally M., Guo, Wenhong, Wang, Hoau-Yan, Burns, Lindsay H., Vanderah, Todd W.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469510/
https://ncbi.nlm.nih.gov/pubmed/18468954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2008.03.005
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