TMEM16A/ANO1 Suppression Improves Response to Antibody Mediated Targeted Therapy of EGFR and HER2/ERBB2

TMEM16A, a Ca(2+)-activated Cl(−) channel, contributes to tumor growth in breast cancer and head and neck squamous cell carcinoma (HNSCC). Here, we investigated whether TMEM16A influences the response to EGFR/HER family-targeting biological therapies. Inhibition of TMEM16A Cl(−) channel activity in...

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Detalhes bibliográficos
Publicado no:Genes Chromosomes Cancer
Main Authors: Kulkarni, Sucheta, Bill, Anke, Godse, Neal R., Khan, Nayel I., Kass, Jason I., Steehler, Kevin, Kemp, Carolyn, Davis, Kara, Bertrand, Carol A., Vyas, Avani R., Holt, Douglas E., Grandis, Jennifer R., Gaither, L Alex, Duvvuri, Umamaheswar
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469289/
https://ncbi.nlm.nih.gov/pubmed/28177558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22450
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