Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1

A dynamic actin cytoskeleton is necessary for viral entry, intracellular migration, and virion release. For HIV-1 infection, during entry, the virus triggers early actin activity by hijacking chemokine coreceptor signaling, which activates a host dependency factor, cofilin, and its kinase, the LIM d...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Yi, Fei, Guo, Jia, Dabbagh, Deemah, Spear, Mark, He, Sijia, Kehn-Hall, Kylene, Fontenot, Jacque, Yin, Yan, Bibian, Mathieu, Park, Chul Min, Zheng, Ke, Park, Ha Jeung, Soloveva, Veronica, Gharaibeh, Dima, Retterer, Cary, Zamani, Rouzbeh, Pitt, Margaret L., Naughton, John, Jiang, Yongjun, Shang, Hong, Hakami, Ramin M., Ling, Binhua, Young, John A. T., Bavari, Sina, Xu, Xuehua, Feng, Yangbo, Wu, Yuntao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469273/
https://ncbi.nlm.nih.gov/pubmed/28381571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02418-16
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