Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network

T-cell development from hematopoietic progenitors depends on multiple transcription factors, mobilized and modulated by intrathymic Notch signaling. Key aspects of T-cell specification network architecture have been illuminated through recent reports defining roles of transcription factors PU.1, GAT...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Longabaugh, William J. R., Zeng, Weihua, Zhang, Jingli A., Hosokawa, Hiroyuki, Jansen, Camden S., Li, Long, Romero-Wolf, Maile, Liu, Pentao, Kueh, Hao Yuan, Mortazavi, Ali, Rothenberg, Ellen V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Sackler Colloquium on Gene Regulatory Networks and Network Models in Development and Evolution
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468679/
https://ncbi.nlm.nih.gov/pubmed/28584128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610617114
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