CCR8(+)FOXp3(+) T(reg) cells as master drivers of immune regulation

The current study identifies CCR8(+) regulatory T cells (T(reg) cells) as drivers of immunosuppression. We show that in human peripheral blood cells, more than 30% of T(reg) up-regulate CCR8 following activation in the presence of CCL1. This interaction induces STAT3-dependent up-regulation of FOXp3...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Barsheshet, Yiftah, Wildbaum, Gizi, Levy, Eran, Vitenshtein, Alon, Akinseye, Chika, Griggs, Jeremy, Lira, Sergio A., Karin, Nathan
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2017
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468670/
https://ncbi.nlm.nih.gov/pubmed/28533380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621280114
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