CCR8(+)FOXp3(+) T(reg) cells as master drivers of immune regulation

The current study identifies CCR8(+) regulatory T cells (T(reg) cells) as drivers of immunosuppression. We show that in human peripheral blood cells, more than 30% of T(reg) up-regulate CCR8 following activation in the presence of CCL1. This interaction induces STAT3-dependent up-regulation of FOXp3...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Barsheshet, Yiftah, Wildbaum, Gizi, Levy, Eran, Vitenshtein, Alon, Akinseye, Chika, Griggs, Jeremy, Lira, Sergio A., Karin, Nathan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468670/
https://ncbi.nlm.nih.gov/pubmed/28533380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621280114
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