The pentameric complex drives immunologically covert cell–cell transmission of wild-type human cytomegalovirus

Human cytomegalovirus (HCMV) strains that have been passaged in vitro rapidly acquire mutations that impact viral growth. These laboratory-adapted strains of HCMV generally exhibit restricted tropism, produce high levels of cell-free virus, and develop susceptibility to natural killer cells. To perm...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Murrell, Isa, Bedford, Carmen, Ladell, Kristin, Miners, Kelly L., Price, David A., Tomasec, Peter, Wilkinson, Gavin W. G., Stanton, Richard J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468625/
https://ncbi.nlm.nih.gov/pubmed/28533400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704809114
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